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New insights into how a molecular gatekeeper controls early protein modification

For years, ETH researchers have been investigating a molecular complex that plays a key role in protein synthesis. They have ...
Nature

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex

Huntington’s disease (HD) (OMIM accession code 143100) is caused by an expanded CAG repeat in exon 1 of the Huntingtin (HTT) gene. HD is characterized by progressive neuronal cell death associated ...